You can create multiple email signatures in Outlook -- one for each email account or a different signature for different canned replies.

1. Click New Email from the Home tab.

2. Click the Signature icon, then click on Signatures tab.

3. Click the New button in the Signatures and Stationery window. Type in a name for the signature and click OK. For example, "Work Signature."

4. Enter your signature in the Edit signature box. You can type in your name, job title, contact information, website address, and any other information you want to quickly insert into new email messages.

5. Click OK. This will be the default signature for new emails sent from your email account.

Insert a Different Email Signature

Repeat the steps above to create additional email signatures, which you can choose to insert on an email-by-email basis by going to the Insert > Signatures menu.